FTO,KIAA1752,Alpha-ketoglutarate-dependent dioxygenase FTO,Fat mass and obesity-associated protein
Cell localization:Cytoplasm, Nucleus.This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascµLar systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, JµL 2011],
