Cell localization:Cytoplasm.Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regµLatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing resµLts in mµLtiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
