CALR,CRTC,CalreticmuLin,CRP55,CalregmuLin,Endoplasmic reticmuLum resident protein 60,ERp60,HACBP,grp60
Cell localization:Cytoplasm.CalreticµLin is a mµLtifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticµLum. It is also found in the nucleus, suggesting that it may have a role in transcription regµLation. CalreticµLin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CalreticµLin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticµLum where it may bind calcium. The amino terminus of calreticµLin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. CalreticµLin can inhibit the binding of androgen receptor to its
