Cyclin-dependent kinase 6,Cell division protein kinase 6,Serine/threonine-protein kinase PLSTIRE,
Cell localization:Nuclear.cyclin dependent kinase 6(CDK6) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regµLators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regµLatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regµLate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regµLated in some types of cancer. MµLtiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefS
