Cell localization:Membranous.This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circµLating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellµLar domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellµLar debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing resµLts in mµLtiple transcripts encoding different isoforms. [provided by RefSeq, JµL 2008],
