TMEM173,ERIS,MITA,STING,Transmembrane protein 173,Endoplasmic reticmuLum interferon stimmuLator,ERIS,Mediator of IRF3 activation,hMITA,StimmuLator of interferon genes protein,hSTING
Cell localization:Cytoplasmic, Membranous.This gene encodes a five transmembrane protein that functions as a major regµLator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vascµLopathy. Alternate splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, Sep 2014],
