SIRT1,SIR2L1,NAD-dependent protein deacetylase sirtuin-1,hSIRT1,RegmuLatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2
Cell localization:Nuclear.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regµLate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellµLar regµLatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, Dec 2008],
