H3 histone, family 3A, H3 histone, family 3B (H3.3B), H3.3A, H3.3B, H33, H3F3, H3F3A, H3F3B, Histone H3.3,,p-Histone H3 (S11)
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
