AGS1, AGS5, CRV, DNase III, DRN3, HERNS, TREX1,,TREX1
Major cellular 3-to-5 DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3 termini.Prevents cell-intrinsic initiation of autoimmunity.Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements.
