Non-biotinylated Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-HM4V8)
Biozol Catalog Number:
KAB-ITG-HM4V8
Supplier Catalog Number:
ITG-HM4V8
Alternative Catalog Number:
KAB-ITG-HM4V8-100UG, KAB-ITG-HM4V8-500UG
Manufacturer:
KactusBio
Category:
Proteine/Peptide
Species Reactivity:
Human
Alternative Names:
alphaVbeta8, Integrin alpha V beta 8, TGAV&ITGB8,Integrin alpha V beta 8
Recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGAV.It contains Phe31-Val992(ITGAV) acidic tail and Glu43-Arg684(ITGB8) basic tail.
Molecular Weight:
The protein has a predicted MW of 114 kDa (ITGAV) and 76 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result.
Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Expression System:
HEK293
Purity:
> 95% as determined by Bis-Tris PAGE,> 90% as determined by HPLC
Form:
Lyophilized
Sequence:
Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail
Target:
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer
Human ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human ITGAV&ITGB8, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.85 ug/ml determined by ELISA (QC Test).
Immobilized Human ITGAV&ITGB8, His Tag at 2ug/ml(100ul/well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.
Loaded Anti-alpha V Ab., hFc Tag on ProA-Biosensor can bind Biotinylated Human ITGAV&ITGB8, His-Avi Tag with an affinity constant of 0.61 µM as determined in BLI assay (Gator Prime).
The purity of Human ITGAV&ITGB8 is greater than 90% as determined by SEC-HPLC.
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