Y-27632 is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-kappaB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade[1][2][3][4][5][6].
Molecular Weight:
247.34
Purity:
99.91
CAS Number:
[146986-50-7]
Formula:
C14H21N3O
Target:
Akt,Apoptosis,Autophagy,mTOR,NADPH Oxidase,NF-kappaB,PAK,Ras,Reactive Oxygen Species (ROS),ROCK
Application Notes:
MCE Product type: Reference compound1
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