(-)-Bicuculline methobromide is a potent GABAA blocker. (-)-Bicuculline methobromide alters membrane properties and firing pattern. (-)-Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. (-)-Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
Molecular Weight:
462.29
Purity:
99.94
CAS Number:
[73604-30-5]
Formula:
C21H20BrNO6
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound1
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