I-XW-053 is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 µM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 µM), I-XW-053 disrupts capsid function and reduces polymerization levels. I-XW-053 effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 can be widely used in studies related to HIV-1 infection[1][2][3][4].
Molecular Weight:
340.38
Purity:
99.71
CAS Number:
[5496-35-5]
Formula:
C22H16N2O2
Target:
HIV,Reverse Transcriptase
Application Notes:
MCE Product type: Reference compound1
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