J-113863 is a potent and selective CCR1 antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-alpha receptors. Anti-inflammatory effect[1][2][3].
Molecular Weight:
655.44
Purity:
99
CAS Number:
[353791-85-2]
Formula:
C30H37Cl2IN2O2
Target:
CCR
Application Notes:
MCE Product type: Reference compound1
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