Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome[1][2][3].
Molecular Weight:
415.01
Purity:
99.87
CAS Number:
[220953-69-5]
Formula:
C24H35ClN4
Target:
CRFR
Application Notes:
MCE Product type: Reference compound1
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