MK-2206 free base is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 free base inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3beta and Mcl-1 via proteasomal degradation. MK-2206 free base induces G1-phase cell cycle arrest, apoptosis (apoptosis), epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 free base causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 free base can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia[1][2][3][4].
Molecular Weight:
407.47
CAS Number:
[1032349-93-1]
Formula:
C25H21N5O
Target:
Akt,Apoptosis,Bcl-2 Family,GSK-3,mTOR
Application Notes:
MCE Product type: Reference compound
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