Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury[1][2].
Molecular Weight:
325.28
Purity:
98.92
CAS Number:
[927685-43-6]
Formula:
C16H14F3NO3
Target:
Apoptosis,PGE synthase,Prostaglandin Receptor,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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