Lixazinone (RS-82856) is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC50 value of 22 nM. Lixazinone exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [32P]cGMP. Lixazinone can be used in the research of polycystic kidney disease and congestive heart failure[1][2][3][4].
Molecular Weight:
384.48
CAS Number:
[94192-59-3]
Formula:
C21H28N4O3
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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