Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC50 of 10 µM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitts lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors[1][2][3].
Molecular Weight:
606.85
CAS Number:
[192658-64-3]
Formula:
C32H58N6O5
Target:
Microtubule/Tubulin,Prolyl Endopeptidase (PREP)
Application Notes:
MCE Product type: Reference compound
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