Pomalidomide 5-pip-acid is an E3 ligase ligand-linker conjugate derived from the molecular glue Pomalidomide (HY-10984), which can be used to synthesize the dual-target PROTAC degrader PROTAC CBP/p300/BRD4 Degrader-1 (HY-181758) targeting CBP/p300 and BRD4. Pomalidomide 5-pip-acid shows anti-proliferative activity against cancer cells with an IC50 of 2.73 nM. Pomalidomide 5-pip-acid induces anti-proliferative effects in cancer cells. Pomalidomide 5-pip-acid is applicable to research related to prostate cancer and colorectal cancer[1].
Molecular Weight:
385.37
Purity:
99.40
CAS Number:
[2467965-70-2]
Formula:
C19H19N3O6
Target:
Drug Derivative,E3 Ligase Ligand-Linker Conjugates
Application Notes:
MCE Product type: Reference compound
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