Human recombinant A2M protein fragment (around aa 600-800) (exact sequence is proprietary)
Alternative Names:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, Alpha-2-M (A2M), CPAMD5
-2-Macroglobulin (-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, -2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on -2M. This interaction induces a conformational change in -2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, -2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor (TGF) in serum is primarily bound to -2M, which renders TGF inactive. -2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding -2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of -2M in mediating the clearance and degradation of A , the major component of -Amyloid deposits accumulated during AD.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified Alpha-2-Macroglobulin Mouse Monoclonal Antibody (A2M/6550). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human colon stained with Alpha-2-Macroglobulin Mouse Monoclonal Antibody (A2M/6550). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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