Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Western Blot (2-4ug/ml), ,Optimal dilution for a specific application should be determined.
Western Blot Analysis of A431 cell lysate using Filaggrin Rabbit Recombinant Monoclonal Antibody (FLG/3909R).
SDS-PAGE Analysis of Purified Filaggrin Recombinant Rabbit Monoclonal Antibody (FLG/3909R). Confirmation of Purity and Integrity of Antibody.
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