Recombinant fragment (around aa100-509) of human PRAME protein (exact sequence is proprietary)
Alternative Names:
Cancer/testis antigen 130, CT130, MAPE, Melanoma antigen preferentially expressed in tumors, OIP 4, OIP-4, OIP4, OPA interacting protein 4, Opa interacting protein OIP4, OPA-interacting protein 4, PRAME, Preferentially expressed antigen in melanoma, Preferentially expressed antigen of melanoma, RP23-250F8.3
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human testis stained with PRAME Rabbit Monoclonal Antibody (PRAME/6928R). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human melanoma stained with PRAME Rabbit Monoclonal Antibody (PRAME/6928R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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