Recombinant fragment (around aa400-592) of human GBP1 protein (exact sequence is proprietary)
Alternative Names:
GTP binding protein 1, Guanine nucleotide binding protein 1, Guanylate binding protein 1 interferon inducible 67kDa, HuGBP1, Interferon induced guanylate binding protein 1, OTTHUMP00000012352
GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis Purified GBP1 Mouse Monoclonal Antibody (GBP1/7618). Confirmation of Purity and Integrity of Antibody.
IHC analysis of formalin-fixed, paraffin-embedded human kidney. GBP1 Mouse Monoclonal Antibody (GBP1/7618). Inset: PBS instead of primary antibody, secondary only negative control.
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