IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody, IgG1, Clone: [SPM188], Mouse, Monoclonal
Biozol Catalog Number:
NBT-3507-MSM1X-P1ABX
Supplier Catalog Number:
3507-MSM1X-P1ABX
Alternative Catalog Number:
NBT-3507-MSM1X-P1ABX-100
Manufacturer:
NeoBiotechnologies
Host:
Mouse
Category:
Antikörper
Application:
FC, IF, IHC
Species Reactivity:
Human
Immunogen:
Heavy chain of human IgM
Alternative Names:
AGM1, IGHM, Constant Region of Heavy Chain of IgM, Ig Mu Chain C Region
Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstroms macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min
Formalin-fixed, paraffin-embedded human Tonsil stained with IgM Monoclonal Antibody (SPM188)
Formalin-fixed, paraffin-embedded human Tonsil stained with IgM Monoclonal Antibody (SPM188)
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