Recombinant fragment (around aa1-100) of human APP protein (exact sequence is proprietary). Recognizes an epitope in the region 8-16 of the amyloid precursor protein.
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the -Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid /A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.
200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
SDS-PAGE Analysis of Purified Beta Amyloid Mouse Monoclonal Antibody (APP/4469). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human brain stained with Beta Amyloid Mouse Monoclonal Antibody (APP/4469). Inset: PBS instead of primary antibody, secondary only negative control.
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