A recombinant fragment (around aa 19-188) of human CD137 protein (exact sequence is proprietary)
Alternative Names:
4-1BB Ligand Receptor T Cell, Antigen 4-1BB Homolog, CDw137, HLDA VI, Homolog of mouse 4 1BB, induced by lymphocyte activation (ILA), Interleukin activated receptor homolog of mouse Ly63, T-cell antigen 4-1BB / ILA homolog, Tumor necrosis factor receptor superfamily member 9
CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal diluti
Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603).
SDS-PAGE Analysis of Purified CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603). Confirmation of Purity and Integrity of Antibody.
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