B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p
Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkins lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow Cytometry (1-2ug/million cells), Western Blot (1-2ug/ml),Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM
Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/1118)
Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B/1118)
Formalin-fixed, paraffin-embedded human Cervical Ca stained with Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/1118)
Purified Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/1118). Confirmation of Integrity and Purity of Antibody.
Immunofluorescent staining of HeLa cells. Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/1118), followed by goat anti-mouse IgG-CF488 (Green).
Flow Cytometric Analysis of HeLa cells using Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/1118), followed bygoat anti-mouse IgG-CF488 (Blue), Unstained cells Control (Red).
Western Blot Analysis of THP-1 and Raji Cell lysate using Beta-2-Microglobulin Mouse Monoclonal Antibody (B2M/1118).
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