A portion of amino acids 61-90 from the human protein was used as the immunogen for this MUC20 antibody.
MUC20 may regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. [UniProt]
Western blot: 1:1000,Immunofluorescence: 1:10-1:50
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the MUC20 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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