Recombinant IgM Heavy Chain Antibody, Clone: [rIGHM/2558], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V7868SAF-100UG
Supplier Catalog Number:
V7868SAF-100UG
Alternative Catalog Number:
NSJ-V7868SAF-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
FACS, IF, IHC-P
Species Reactivity:
Human
Immunogen:
Heavy chain of human IgM was used as the immunogen for the recombinant IgM Heavy Chain antibody.
Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstroms macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
