CD54 (Intercellular Adhesion Molecule, ICAM-1) (FITC), Clone: [YN1/1.7.4], Rat, Monoclonal
Biozol Catalog Number:
USB-C2409-19H
Supplier Catalog Number:
C2409-19H
Alternative Catalog Number:
USB-C2409-19H-500
Manufacturer:
US Biological
Host:
Rat
Category:
Antikörper
Application:
FC, IHC, IP, WB
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN-gamma, IL-1, TNF-alpha, lipopolysaccharide and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1. Applications: Flow cytometry 2 Immunohistochemistry (frozen sections) 4 Immunoprecipitation 2 In vitro blocking studies 1 Western blotting 3 Recommended Dilution: Flow Cytometry: 1ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20C or colder. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clonality:
Monoclonal
Clone Designation:
[YN1/1.7.4]
Purity:
Purified
Form:
Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with FITC.
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