CD54 (Intercellular Adhesion Molecule, ICAM-1) (PE), Clone: [5K16], Rat, Monoclonal
Biozol Catalog Number:
USB-C2409-19K
Supplier Catalog Number:
C2409-19K
Alternative Catalog Number:
USB-C2409-19K-100
Manufacturer:
US Biological
Host:
Rat
Category:
Antikörper
Application:
FC, IHC, IP, WB
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN-gamma, IL-1, TNF-alpha, lipopolysaccharide and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry, Immunoprecipitation, In vitro blocking studies and Western Blot. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.2ug/10e6 cells Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Clonality:
Monoclonal
Clone Designation:
[5K16]
Purity:
Purified
Form:
Supplied as a liquid in PBS, 0.09% sodium azide and a stabilizing agent. Labeled with R-Phycoerythrin (PE).
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