IRAK 4, NT (Interleukin-1 Receptor-associated Kinase 4, IRAK4, IRAK-4, IPD1, REN64, Renal Carcinoma Antigen NY-REN-64), Rabbit
Biozol Catalog Number:
USB-I8600-18H
Supplier Catalog Number:
I8600-18H
Alternative Catalog Number:
USB-I8600-18H-50
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
FC, IHC, IP, WB
Immunogen:
Mixture of synthetic peptides containing amino acids 38-54 and 120-136 of mouse IRAK-4. Species sequence homology: rat
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families. Applications: Suitable for use in Western Blot, Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Positive Control: NIH 3T3 Whole Cell Lysate IRAK4 Overexpression Lysate Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity:
Purified by Protein G affinity chromatography.
Form:
Supplied as a liquid in PBS, 0.05% sodium azide.
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