Full-length recombinant proteiin corresponding to aa57-67 from human survivin. Epitope: aa57-67. Cellular Localization: Cytoplasmic.
Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. Inhibitor of Apoptosis (IAP) proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminus RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique IAP. Present during fetal development, survivin is undetectable in terminally differentiated adult tissues. However, survivin becomes prominently expressed in transformed cell lines and in all the most common human cancers of lung, colon, pancreas, prostate and breast in vivo. Survivin is also found in high-grade non-Hodgkins lymphomas. These data suggest that apoptosis inhibition may be a general feature of neoplasia and identify survivin as a potential new target for apoptosis-based therapy in cancer and lymphoma. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry and Immunofluorescence. Other applications have not been tested. Recommended Dilution: Immunohistochemistry: Paraffin sections Optimal dilutions to be determined by the researcher. Positive Control: HeLa whole cell extract Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clonality:
Monoclonal
Clone Designation:
[3H1 60.11]
Purity:
Purified by Protein G affinity chromatography.
Form:
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
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