Synthetic peptide (AKTTRQSIEQLAA) corresponding to amino acids 128 to 140 of mouse origin.
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3). Applications: Suitable for use in Western Blotting. Other applications not tested. Recommended Dilution: Western Blotting: 0.5-1ug/ml. Optimal dilutions to be determined by the researcher. Positive Control: Mouse spleen tissue lysate Storage and Stability: May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Supplied as immunoaffinity purified IgG
Form:
Supplied as a liquid in PBS, 0.02% sodium azide.
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