TAO Kinase 1 (Thousand and One Amino Acid Protein Kinase 1, TAOK1, hTAOK1, TAO1, Kinase from Chicken Homolog B, KFC-B, hKFC-B, KIAA1361, MAP3K16, MARK Kinase, MARKK, Prostate-derived Sterile 20-like Kinase 2, Prostate-derived STE2
Catalog Number:
USB-T0649-90B
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| Article Name: | TAO Kinase 1 (Thousand and One Amino Acid Protein Kinase 1, TAOK1, hTAOK1, TAO1, Kinase from Chicken Homolog B, KFC-B, hKFC-B, KIAA1361, MAP3K16, MARK Kinase, MARKK, Prostate-derived Sterile 20-like Kinase 2, Prostate-derived STE2 |
| Biozol Catalog Number: | USB-T0649-90B |
| Supplier Catalog Number: | T0649-90B |
| Alternative Catalog Number: | USB-T0649-90B-200 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Synthetic peptide selected from the center region of human TAOK1 (KLH). |
| TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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