TBP, CT (TATA-box-binding Protein, TATA-box Factor, TATA-binding Factor, TATA Sequence-binding Protein, Transcription Initiation Factor TFIID TBP Subunit, TFIID, TF2D, GTF2D1), Rabbit
Catalog Number:
USB-T0700-90A
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| Article Name: | TBP, CT (TATA-box-binding Protein, TATA-box Factor, TATA-binding Factor, TATA Sequence-binding Protein, Transcription Initiation Factor TFIID TBP Subunit, TFIID, TF2D, GTF2D1), Rabbit |
| Biozol Catalog Number: | USB-T0700-90A |
| Supplier Catalog Number: | T0700-90A |
| Alternative Catalog Number: | USB-T0700-90A-200 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Synthetic peptide selected from the C-terminal region of human TBP (KLH). |
| Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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