Tamm-Horsfall Urinary Glycoprotein (UMOD, Uromodulin, THP) (FITC), IgG2b, Clone: [10.32], Mouse, Monoclonal
Catalog Number:
USB-T0850-03
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| Article Name: | Tamm-Horsfall Urinary Glycoprotein (UMOD, Uromodulin, THP) (FITC), IgG2b, Clone: [10.32], Mouse, Monoclonal |
| Biozol Catalog Number: | USB-T0850-03 |
| Supplier Catalog Number: | T0850-03 |
| Alternative Catalog Number: | USB-T0850-03-50 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FLISA, IF, IHC |
| Immunogen: | Human Tamm-Horsfall protein. Species sequence homology: canine. |
| Tamm-Horsfall glycoprotein (THP, Uromodulin) is a 105-120kD urinary glycoprotein. It is secreted by renal tubule epithelium, acts as a binding protein for IL-1, TNF-alpha and C1q, activates resting monocytes, and promotes neutrophil phagocytosis. Uromodulin forms high molecular weight oligomers that line the kidney tubules. Mouse Uromodulin is GPI-linked. Its proprecursor is 619aa in length. It contains three EGF-like domains (aa28-148), a ZP domain that mediates oligomerization (aa335-590), and a cleavable C-terminal propeptide (aa619- 642). There are multiple splice variants. One shows an alternate start site at Met343, and there are two substitutions, a 17aa substitution for aa601-642, and a 166aa substitution for aa441- 642. Over aa25-614, mouse Uromodulin shares 78% and 89% aa identical to human and rat Uromodulin, respectively. Applications: Suitable for use in Immunohistochemistry, FLISA and Immunofluorescence. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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