Tamsulosin, Hydrochloride (LY-253351, YM-12617-1, YM-617), CAS [[106463-17-6]]
Biozol Catalog Number:
USB-T0880
Supplier Catalog Number:
T0880
Alternative Catalog Number:
USB-T0880-100,USB-T0880-1
Manufacturer:
US Biological
Category:
Biochemikalien
A selective alpha-1A adrenoceptor antagonist that has preferential selectivity for the alpha-1A adrenoceptor in the prostate versus the alpha-1B adrenoceptor in the blood vessels (pKi values are 9.97, 9.64 and 8.86 for alpha-1A, alpha-1B and alpha-1D subtypes respectively). Used for treatment of difficult urination, a common symptom of enlarged prostate. Has negligible effect on arterial blood pressure in vivo Useful as a drug in combination therapy for the treatment of benign prostatic hyperplasia (BPH) and urinary symptoms associated with an enlarged prostate. Tamsulosin has been shown to have a significant effect on BPH symptoms and urinary flow rates, as well as improved quality of life. The combination therapy group showed significant improvements in both of these areas when compared with the control group, which consisted of men who were given placebo pills instead of tamsulosin. Synonyms: LY-253351, YM-12617-1, YM-617, Flomax, Harnal, Omnic, Pradif, 5-[(2R)-2-[[2-(-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride, 5-[(R)-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride CAS No: 106463-17-6 Molecular Formula: C20H29ClN2O5S Molecular Weight: 444.97 Appearance: White to off-white solid Purity: 98% (T)(HPLC) Melting Point: 228-230C Specific Rotation: [a]20/D -17.5 to -20.5 deg(C=1, H2O) Solubility: Methanol Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
444.97
Purity:
98% (T)(HPLC)
Form:
White to off-white solid
CAS Number:
[106463-17-6]
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