TARDBP (TAR DNA Binding Protein, ALS10, TDP-43, OTTHUMP00000002171, TAR DNA-binding protein-43), Goat
Biozol Catalog Number:
USB-T1019-42
Supplier Catalog Number:
T1019-42
Alternative Catalog Number:
USB-T1019-42-100
Manufacturer:
US Biological
Host:
Goat
Category:
Antikörper
Application:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to HISNAEPKHNSNRQ from the internal region of human TARDBP (NP_031401). Species Sequence Homology: canine, bovine, rat, porcine
TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene. Applications: Suitable for use in Peptide ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Peptide ELISA: 1:16,000 Western Blot: 0.3-1ug/ml Detects ~45kD band in human Jurkat and NIH3T3 cell lysates. A slightly larger protein is detected in some regins of the brain. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
