Taste Receptor 1 (TR1) (Not for Export EU), Rabbit
Biozol Catalog Number:
USB-T1024-01C
Supplier Catalog Number:
T1024-01C
Alternative Catalog Number:
USB-T1024-01C-100
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
ELISA
Immunogen:
KLH-conjugated 24-amino acid peptide sequence near the C-terminus of rat TR1. This sequence has no significant homology with TRS or gustducin or pheromone receptors. Species sequence homology: mouse (100%), human (87%).
Higher vertebrates are believed to possess at least five basic tastes: Sweet, bitter, sour, salty, and unami (the taste of monosodium glutamate). Taste receptor cells selectively reside in various parts of the tongue and respond to different tastants and perceive these taste modalities. Circumvallate papillae, found at the very back of the tongue, are particularly sensitive to biter substances. Foliate papillae, found at the posterior lateral edge of the tongue, are sensitive to sour and bitter. Fungiform papillae at the front of the tongue specialize in sweet taste. Recently, two novel taste receptors, TR1 and TR2, have been cloned with distinct topographical distribution in taste receptor cells and taste buds. TRs are members of a new group of 7 TM domain containing GPCR distantly related to other chemosensory receptors (Ca+-sensing receptor (CaSR), a family of putative hormone receptor (V2R), and metabotropic glutamate receptors). TR1 is expressed in all fungiform taste buds, whereas TR2 is localized to the circumvallate taste buds. Both receptors do not colocalize with gustducin. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilution: ELISA: 1:5000-25,000. Control peptide can be used to coat ELISA plates at 1ug/ml. Western Blot: 1:500-1:2500. Optimal dilutions to be determined by the researcher. Control peptide: T1024-01B Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. . For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
Serum
Form:
Supplied as lyophilized antiserum containing 0.05% sodium azide. Reconstitute with 100ul sterile PBS.
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