Tau (microtubule-associated protein tau, DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, Microtubule-associated protein tau, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, PPND, tau, TAU) (Bi
Catalog Number:
USB-T1030-10A-BIOTIN
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| Article Name: | Tau (microtubule-associated protein tau, DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, Microtubule-associated protein tau, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, PPND, tau, TAU) (Bi |
| Biozol Catalog Number: | USB-T1030-10A-BIOTIN |
| Supplier Catalog Number: | T1030-10A-Biotin |
| Alternative Catalog Number: | USB-T1030-10A-BIOTIN-100 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | WB |
| Immunogen: | KLH conjugated synthetic linear peptide. |
| Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Human brain tissue lysate. Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody. |
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