Tau (Tau Protein, Microtubule-associated Protein, MAP) (MaxLight 490), IgG1, Clone: [0.T.147 5E2], Mouse, Monoclonal
Catalog Number:
USB-T1030-ML490
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| Article Name: | Tau (Tau Protein, Microtubule-associated Protein, MAP) (MaxLight 490), IgG1, Clone: [0.T.147 5E2], Mouse, Monoclonal |
| Biozol Catalog Number: | USB-T1030-ML490 |
| Supplier Catalog Number: | T1030-ML490 |
| Alternative Catalog Number: | USB-T1030-ML490-100 |
| Manufacturer: | US Biological |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FLISA, IHC, WB |
| Immunogen: | Human fetal heat-stable MAPS. Species sequence homology: rat and bovine |
| MaxLight(TM)490 is a new Blue-Green photostable dye conjugate comparable to DyLight(TM)488, Alexa Fluor(TM)488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm), Emission (515nm), Extinction Coefficient 73,000. Tau is a heterogeneous group of proteins that range in molecular weight from 50-67kD. They are instumental in the assembly of microtubules and have been associated with some disease states. In normal brain, tau is localized in the axons of the neurons but in some neuropathological lesions, it accumulates within the body of the neuron. Tau protein is a microtubule-associated protein predominantly localized to neuronal axons. Tau promotes tubulin polymerization and the stabilization of microtubules. In vivo this protein is enriched in the exonal compartment of neurons wherer it has a role in the rapid elongation of the axon. Hyperphosphorylated forms of Tau are the major components of paired helical filaments (PHF) found in the neurofibrillary tangles which characterize Alzheimers disease. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau. Applications: Suitable for use in FLISA, Western Blot and Immunhistochemsitry. Other applications not tested. Recommended Dilutions: Western Blot: detected tau proteins (50-70kD) in rat brain preparations. Immunohistochemistry: detected tau proteins in rat brain sections. Optimal dilutions to be determined by the researcher.. Storage and Stability: Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight(TM)490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody. |
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