TTC8 (Tetratricopeptide Repeat Protein 8, TPR Repeat Protein 8, Bardet-Biedl Syndrome 8 Protein, BBS8), Goat
Biozol Catalog Number:
USB-T3503-28A
Supplier Catalog Number:
T3503-28A
Alternative Catalog Number:
USB-T3503-28A-100
Manufacturer:
US Biological
Host:
Goat
Category:
Antikörper
Application:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to C-KEVLKQDNTHVE, from human TTC8, at the Internal region of the protein (NP_653197.2, NP_938051.1, NP_938052.1).
The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 0.2-0.6ug/ml, human testis lysates observed on ~60kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
