TGIF1 Rabbit pAb, Polyclonal
Artikelnummer:
ABB-A16984
- Bilder (1)
| Artikelname: | TGIF1 Rabbit pAb, Polyclonal |
| Artikelnummer: | ABB-A16984 |
| Hersteller Artikelnummer: | A16984 |
| Alternativnummer: | ABB-A16984-20UL,ABB-A16984-100UL,ABB-A16984-1000UL,ABB-A16984-500UL |
| Hersteller: | ABclonal |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC-P, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Alternative Synonym: | HPE4, TGIF, TGIF1 |
| The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. |
| Application Verdünnung: | WB,1:500 - 1:1000|IHC-P,1:50 - 1:200|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Anwendungsbeschreibung: | Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Epigenetics Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Signal Transduction,Cell Biology Developmental Biology,Neuroscience,Stem Cells,Embryonic Stem Cells,Neural Stem Cells. Shipping: Ice Bag |
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Western blot analysis of various lysates using TGIF1 Rabbit pAb (A16984) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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