Polyclonal Antibody to ABL1/2 (Ab-393/439), Rabbit
Artikelnummer:
ABI-35-1738-50
Hersteller Artikelnummer:
35-1738-50
Alternativnummer:
ABI-35-1738-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse
Immunogen:
Peptide sequence around aa.391~395/437~441(D-T-Y-T-A) derived from Human ABL1/2.
Alternative Synonym:
ABL|| v-abl|| c-ABL|| p150|| JTK7
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N.N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.
