Polyclonal Antibody to ABL1/2 (Ab-393/439), Rabbit
Biozol Catalog Number:
ABI-35-1738-50
Supplier Catalog Number:
35-1738-50
Alternative Catalog Number:
ABI-35-1738-50-50UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human, Mouse
Immunogen:
Peptide sequence around aa.391~395/437~441(D-T-Y-T-A) derived from Human ABL1/2.
Alternative Names:
ABL|| v-abl|| c-ABL|| p150|| JTK7
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N.N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.
