The immunogen is a synthetic peptide directed towards the C terminal region of human NR1D2
Alternative Synonym:
RVR, BD73, EAR-1R, REVERBB, REVERBbeta
NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5-AATGTAGGTCA-3 and 5-ATAACTAGGTCA-3 and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.