Recombinant Human Methylosome protein 50 protein (1-260AA)
Konjugation:
Unconjugated
Alternative Synonym:
androgen receptor cofactor p44,HKMT1069,MEP50,MEP-50,methylosome protein 50,Nbla10071,p44,p44/Mep50,testis tissue sperm-binding protein Li 44a,WD repeat-containing protein 77.
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).