Topoisomerase I Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE02703
Hersteller Artikelnummer:
AMRe02703
Alternativnummer:
EKL-AMRE02703-50UL, EKL-AMRE02703-100UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
TOP1, DNA topoisomerase 1, DNA topoisomerase I
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5-OH DNA strand.
